GLIOBLASTOMA MOUSE MODEL DEVELOPMENT & THE FUTURE OF GBM RESEARCH
Orthotopic Models, Focal Radiation and More For Your Preclinical Studies
In GBM research, a clinically relevant glioblastoma mouse model combined with advanced translational oncology approaches enable accurate assessment of drug delivery to the brain. Specialized surgical skills and imaging allow for the development and assessment of orthotopic models, which have been shown to retain the same genomic, histological, epigenetic, and treatment response characteristics as parental tumors and identify the gene signatures and pathways signatures associated with the clinical aggressiveness of GBMs.1,2 Additionally, focal radiation affords researchers the ability to develop more disease-relevant patient-derived xenograft (PDX) models and to more closely mimic clinical scenarios.