How do you ensure the quality and accuracy of your cancer models?

Every model undergoes a rigorous quality control process:

  • WES and RNAseq data from each PDX, CDX and PDX-derived cell line model in the Certis tumor bank is analyzed by our bioinformatics team to confirm genetic fidelity of the model over serial passaging. The quality and concordance of Certis’ cancer models with TCGA ensure consistency and certainty, providing drug developers with clinically relevant models for cancer research.
  • We apply spectral flow cytometry and immunohistochemistry techniques to verify the murine content in all of our cancer models.
  • The Certis in-house data science team conducts regular quality control checks of the tumor bank. Our data scientists review gene coverage and remove murine contamination where applicable.