At Certis, each PDX, CDX and PDX derived cell line model is genetically sequenced using next-generation technology; WES and RNAseq data is analyzed to confirm genetic fidelity of the model over serial passaging. We also apply spectral flow cytometry and immunohistochemistry techniques to verify the murine content in all of our models.
The Certis in-house bioinformatics team also conducts regular quality control checks of the Tumor Bank. Our data scientists review gene coverage and remove murine contamination where applicable. Learn more about our bioinformatics capabilities.