How many times does Certis typically passage a tumor model?

The Certis Tumor Bank is made up of low-passage tumors that are typically passaged less than 10 times. On average, a typical tumor model on study is run between passages 3 and 6. The exact number of passages on any given model depends on your model of interest and study design.

Using low-passage tumors to develop our PDX models ensures that they retain the original tumor characteristics, including the histological architecture, biomarker signatures, driver mutations and gene expressions.1

1 Shi J, Li Y, Jia R, Fan X. The Fidelity of Cancer Cells in PDX Models: Characteristics, Mechanism and Clinical Significance. Int J Cancer. 2020;146(8):2078-2088.